Lublin History of modern multiple sclerosis therapy
نویسنده
چکیده
The earliest recorded description of multiple sclerosis (MS) dates back to the 14th century, but it was the French neurologist, Jean-Martin Charcot (1825–1893), who made the first definite links between the symptoms of MS and the pathological changes seen in post-mortem samples. He described the condition as “sclerose en plaques” and recognised MS as a distinct disease entity. Charcot’s contribution extended to the development of diagnostic criteria, which included the now-famous triad of “nystagmus, tremor and scanning speech”. He also identified many important histological features, including loss of myelin. This paper reviews the development of current treatment strategies for MS.
منابع مشابه
Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis.
1aforearlymultiplesclerosis:CHAMPStrialsubgroup analyses. Ann Neurol. 2002;51:481-490. 42. Hadjimichael O, Vollmer TL. Adherence to injection therapy in multiple sclerosis: patients survey. Neurology. 1999;52:A549. 43. The IFNB Multiple Sclerosis Study Group and the University of British Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interfer...
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